Protective role of FoxO transcription factors against oxidative stress-induced chondrocyte dysfunction: a new therapeutic target for osteoarthritis / 中国药理学与毒理学杂志

ABSTRACT

Chondrocyte dysfunction has been demonstrated to be a major inducer of osteoarthritis(OA). The pathological mechanism of chondrocyte dysfunction is definitely multifactoral, but oxidative stressis regarded as one of the leading causes of apoptosis, autophagy, senescence, and mitochondrial dysfunctionin chondrocytes. Strategies for arresting oxidative stress- induced chondrocyte dysfunction have been considered as potential therapeutic targets for OA. Recently, fork head box O (FoxO) transcription factors have been determined to play a protective role in chondrocytes through the regulation of autophagy and defense against oxidative stress; they also regulate growth, maturation, and matrix synthesis. To explore FoxO' s potential role in the treatment of OA, we first discussed the recent advances in the field of oxidative stress- induced chondrocyte dysfunction and then emphasized the protective role of fox otranscription factors as a potential molecular target for the treatment of OA. Understanding the function of fox otranscription factors will be important in designing next- generation therapies to prevent or reverse the development of OA.