FGF23-Klotho and its correlation with abnormal bone metabolism / 中华检验医学杂志

ABSTRACT

Skeletal metabolic disorder refers to multi-factors caused by bone tissue calcium, phosphorus and other minerals,osteoblasts and(or)osteoclast dysfunction.The FGF23-Klotho axis plays an important role in the bone-kidney-parathyroid axis and is involved in the regulation of bone mineral metabolism.At the same time, FGF23-Klotho axis affects the synthesis and secretion of vitamin D and parathyroid hormone.With the deepening of research,the FGF23-Klotho axis is promising to be the target of diagnosis and treatment of bone metabolic disorders.