Progress of cytokine release syndrome caused by chimeric antigen receptor T-cell immunotherapy / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
; (12): 697-701, 2017.
Article
in Zh
| WPRIM
| ID: wpr-667748
Responsible library:
WPRO
ABSTRACT
As a novel immune therapy for cancer, chimeric antigen receptor T-cell (CAR-T) immunotherapy has attracted more and more attention. Toxicities of CAR-T therapy include cytokine release syndrome (CRS), neurologic toxicities and on-target, off-tumor toxicity. CRS, which is the most severe adverse event of CAR-T immunotherapy, affects many organs, such as cardiovascular, nervous, digestive, hematological systems, and so on. Besides symptomatic treatment, tocilizumab (anti-interleukin monoclonal 6 antibody), etanercept (anti-tumor necrosis factor monoclonal antibody) and glucocorticoid are the core treatments to control CRS. Better understanding of CRS promotes the application of CAR-T immunotherapy.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Journal of Leukemia & Lymphoma
Year:
2017
Document type:
Article