The levels of complement component 3, complement component 4, high sensitivity C reactive protein, and uric acid in serum of schizophrenia / 中国神经精神疾病杂志

ABSTRACT

Objective To examine serum levels of complement component 3(C3), complement component 4(C4), high sensitivity C reactive protein (hs-CRP), and uric acid (UA) in schizophrenia (SZ) patients and study their clinical significance. Methods One hundred forty-four SZ patients were recruited as SZ group. According to use of antipsychotics within four weeks, patients were divided into drug group (77 cases) and non-drug group (67 cases). One hundred forty-seven healthy subjects from health checkup center in the second XiangYa hospital during the same period were selected as control group. The concentrations of serum C3, C4, hs-CRP, and UA from SZ patients and healthy subjects were measured using immuno-scatter turbidmetry, latex-enhanced immunoturbidimetric assay, urea oxidase method, respectively. Results The serum levels of complement C3 and C4 were lower in SZ patients than in control group [(0.99±0.17) g/L vs. (1.03±0.17) g/L、(0.21±0.05) g/L vs. (0.23±0.05) g/L], and the serum levels of UA in serum of was higher in SZ patients than in control group [(351.61±95.90) μmol/L vs. (300.28±39.57) ?mol/L]. The differences had statistical significance (P<0.05, P<0.05, and P<0.001, respectively). The serum levels of C3, C4, hs-CRP, and UA were higher in drug group than in no-drug group [(1.04±0.19) g/L vs. (0.95±0.15) g/L、(0.22±0.06) g/L vs. (0.20±0.05) g/L、1.08(0.33, 5.04) mg/L vs. 0.47(0.28, 1.29) mg/L、(374.54±108.33)μmol/L vs. (331.61±79.03)μmol/L], and the differences had statistical significance (P<0.01).The concentrations of serum hs-CRP and UA were higher in drug group than in control group[1.08(0.33, 5.04) mg/L vs. 0.61(0.33, 1.26) mg/L、(374.54±108.33) μmol/L vs. (300.28±39.57) μmol/L], and differences had statistical significance (P<0.001). Conclusion The serum levels of C3, C4, hs-CRP, and UA in SZ Patients will be of guiding significance for clinical diagnosis of SZ and efficacy evaluation of antipsychotic drugs.