Establishment of animal model of peri-implantitis / 实用口腔医学杂志

ABSTRACT

Objective:To establish peri-implantitis model in beagle dog. Methods:Mandibular first, second and third premolar and first morlar of 5 beagle dogs were extracted. 3 months after tooth extraction,6 branemark pure titanium implants were bilaterally inserted into the posterior mandible in each dog. After healing-abutment connection, cotton ligatures were placed around the healing-abutments and then plaque was accumulated. Clinical and radiographic recording were repeated 1,3 and 5 months respectively after baseline data had been obtained. Surgical recording and pathological changes of peri-implant bone morphology were studied. Results:1,3 and 5 months after the formation of ligature-induced peri-implant inflammation, plaque index,pocket depth and gingival index were singnificantly increased(P