Clinical Effects of Meropenem in the Treatment of Severe Bacterial Lung infection / 中国药师

ABSTRACT

Objective:To observe the clinical effects and adverse reactions of meropenem in the treatment of severe lung infection. Methods:Totally 62 severe bacterial lung infection patients were randomly divided into two groups randomly. The patients in the con-trol group (31 cases ) were treated with cefoperazone / sulbactam 2-8 g in 100 ml 0. 9% sodium chloride injections,ivd,q12h, and the treatment group (31 cases ) was treated with meropenem 1 g in 100 ml 0. 9% sodium chloride injections,ivd,q8h. The treatment course was 14 days. The bacterial clearance rate, dual infection rate, clinical efficacy and adverse drug reactions of the two groups were observed and compared. Results:The bacterial clearance rate in the control group was 85. 2% and that in the treatment group was 92. 85% (P>0. 05). The incidence rate of dual infection in the treatment group (3. 6%) was significant lower than that in the control group (P0. 05). Conclusion:Meropenem is ef-fective in the treatment of severe bacterial lung infection. It can clear bacteria and reduce dual infection effectively, which shows better efficacy than cefoperazone / sulbactam.