Long-Term Outcomes of NSAID-Induced Small Intestinal Injury Assessed by Capsule Endoscopy in Korea: A Nationwide Multicenter Retrospective Study
Gut and Liver
; : 727-733, 2015.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-67333
Responsible library:
WPRO
ABSTRACT
BACKGROUND/AIMS:
We evaluated the long-term outcome and clinical course of patients of nonsteroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by performing capsule endoscopy (CE).METHODS:
A multicenter retrospective study was conducted using data collected from the CE nationwide database registry, which has been established since 2002.RESULTS:
A total of 140 patients (87 males; mean age, 60.6+/-14.8 years) from the CE nationwide database registry (n=2,885) were diagnosed with NSAID-induced small intestinal injury and enrolled in our study. Forty-nine patients (35.0%) presented with a history of aspirin use and an additional 49 (35.0%) were taking NSAIDs without aspirin. The most prominent findings after performing CE were multiple ulcerations (n=82, 58.6%) and erosions or aphthae (n=32, 22.9%). During the follow-up period (mean, 15.9+/-19.0 months; range, 0 to 106 months), NSAID-induced small intestinal injury only recurred in six patients (4.3%). Older age and hypertension were positive predictive factors for recurrence.CONCLUSIONS:
These results suggest that the recurrence of NSAID-induced small bowel injury was not frequent in the presence of conservative treatment. Therefore, the initial diagnosis using CE and the medication history are important.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Time Factors
/
Ulcer
/
Anti-Inflammatory Agents, Non-Steroidal
/
Aspirin
/
Retrospective Studies
/
Age Factors
/
Capsule Endoscopy
/
Republic of Korea
/
Intestinal Diseases
Type of study:
Observational study
/
Prognostic study
Limits:
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Gut and Liver
Year:
2015
Document type:
Article