Combined Antimutagenic Action of Vitamin E and Sodium Selenite / 环境与健康杂志

ABSTRACT

Objective To observe the antimutagenic action of sodium selenite and vitamin E on condensates of cooking oil fumes(COF) Methods SCE (sister chromatid exchanges) were observed and contrasted before and after addition of sodium selenite or vitamin E at a certain dose to the culture of human peripheral blood lymphocytes treated by COF Results Sodium selenite added to lymphocytic culture treated by COF at 37 ℃ for 4 hour incubation significantly lowered the frequencies SCEs of lymphocytes and very significant synergistic effects on lowering frequencies of SCEs were observed during adding both sodium selenite(terminal concentration 0 9?10 -7 mol/L) and vitamin E(torminal concentration 0 1% (v/v) to lymphocytic culture treated ty COF for 4 hour incubation Conclusion Combined sodium selenite and vitamin E at certain concentrations in cultured lymphocytes for 4 hour incubation showed very significant synergistic effects on lowering the mutagenicity of lymphocytes induced ty COF.Sodium selenite alone was also shown to be effective in lowering the frequencies of SCEs of human peripheral blood lymphocytes