Association between Graves'disease and polymorphism of CTLA-4 gene in patients of the Han nationality in Tianjin area / 中华内分泌代谢杂志

ABSTRACT

The polymorphism of (AT) repeat within the 3' untranslated region in exon 3 of CTLA-4 gene was evaluated by PCR-SSCP in 139 patients with Graves' disease (GD) and 110 normal subjects in Tianjin. The gene frequency of 106 bp in patients with GD was significantly increased than that in the control group (RR =1.992,P