Atoh1 as a Coordinator of Sensory Hair Cell Development and Regeneration in the Cochlea / 전남의대학술지
Chonnam Medical Journal
; : 37-46, 2017.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-67656
Responsible library:
WPRO
ABSTRACT
Cochlear sensory hair cells (HCs) are crucial for hearing as mechanoreceptors of the auditory systems. Clarification of transcriptional regulation for the cochlear sensory HC development is crucial for the improvement of cell replacement therapies for hearing loss. Transcription factor Atoh1 is the key player during HC development and regeneration. In this review, we will focus on Atoh1 and its related signaling pathways (Notch, fibroblast growth factor, and Wnt/β-catenin signaling) involved in the development of cochlear sensory HCs. We will also discuss the potential applicability of these signals for the induction of HC regeneration.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Regeneration
/
Transcription Factors
/
Cochlea
/
Fibroblast Growth Factors
/
Hair
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Hair Cells, Auditory
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Hearing
/
Hearing Loss
/
Mechanoreceptors
Language:
English
Journal:
Chonnam Medical Journal
Year:
2017
Document type:
Article