Association of expression of prepro-orexin and orexin receptors with hypothalamic-pituitary-adrenal axis in obese rats / 中华内分泌代谢杂志

ABSTRACT

Expression of prepro-orexin gene in the hypothalamus was decreased in rats with dietary obesity,and has no correlation with serum corticosterone concentration.Expression of orexin receptor-2 in adrenal was increased in obese rats,and was positively correlated to expression of CRH mRNA and inversely correlated to serum corticosterene concentration.