Detection of mutations of exons 5 and exons 8 of PTEN gene in oral squamous cell carcinoma / 实用口腔医学杂志
Journal of Practical Stomatology
; (6)2001.
Article
in Zh
| WPRIM
| ID: wpr-676879
Responsible library:
WPRO
ABSTRACT
Objective:To detect mutations of exons 5 and exons 8 of PTEN gene in oral squamous cell carcinoma(OSCC),and to explore the relationship between gene mutations and development of OSCC.Methods: Mutations of exons 5 and exons 8 of PTEN gene were detected by polymerase chain reaction-single strand conformation polymorphism(PCR-SSCP).Results: The whole sequences of exons 5 and exons 8 of PTEN gene of all cases of OSCC were expanded.There was no mutation in exons 5 and exons 8 of PTEN gene of all cases of OSCC.Conclusion: There is no mutation in exon 5 and exon 8 of PTEN gene in OSCC.This might show that there is no correlation between mutations in exon 5 and exon 8 of PTEN gene and the development of OSCC.
Full text:
1
Database:
WPRIM
Type of study:
Diagnostic_studies
Language:
Zh
Journal:
Journal of Practical Stomatology
Year:
2001
Document type:
Article