Pharmacokinetics of diclofenac sodium microemulsions in rabbits / 第二军医大学学报
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-677185
Responsible library:
WPRO
ABSTRACT
Objective:
To study the pharmacokinetic progress of diclofenac sodium microemulsions in rabbits.Methods:
Diclofenac sodium microemulsion and diclofenac sodium suspension were single orally given to rabbits. Diclofenac sodium concentrations in plasma were measured by HPLC method.Results:
AUC 0 ∞ , c max1 and t max1 were 13.456 ?g?h?ml -1 , 2.852 ?g/ml and 1.438 h after po diclofenac sodium microemulsion and 10.584 ?g?h?ml -1 , 3.145 ?g/ml and 0.750 h after po diclofenac sodium suspension.Conclusion:
The absorption of diclofenac sodium microemulsions in rabbits is slower and can keep a higher concentration in plasma for a long time compared with those of the suspension. [
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2000
Document type:
Article