The effect of A_(1015) on DNA synthesis of D-galactosamine damaged mice hepatotoxicity / 中国药理学通报

ABSTRACT

AIM To study the effect of A 1015 on D galactosamine induced mice hepatotoxicity. METHODS The effect of three doses of A 1015 on DNA biosynthesis of D galactosamine induced mice hepatotoxicity were tested. The time curve of A 1015 on DNA synthesis of D GL induced mice hepatotoxicity was also observed. RESULTS The experiments demonstrated that 2 5 mg?kg -1 is the optimum dose for A 1015 to show liver protective activity. The results suggested that HGF can not only offset the hepatotoxicity induced by D GL, but also promote the DNA synthesis of mice liver cells. And the highest DPM value for HGF group is higher than that of A 1015 group. Thus both HGF and A 1015 showed anti hepatotoxic activity and promoting activity on mice liver cell DNA synthesis. CONCLUSION A 1015 may reduce liver necrosis induced by D galactosamine and promote the DNA synthesis of mice liver cells.