Transplantation of mesencephalon progenitor cells in treatment of Parkinsonian rats / 第二军医大学学报
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-678563
Responsible library:
WPRO
ABSTRACT
Objective:
To explore the feasibility of mesencephalon progenitor cells as dopamine neuron's graft in treatment of Parkinson disease(PD) in rats.Methods:
Animal model of PD were established in SD rats by 6 hydroxydopamine. Mesencephalon progenitor cells were obtained from 13 day old fetal rats. After in vitro proliferation and differentiation, the cells were planted into PD rat striatum.Results:
Progenitor cells were expanded in an undifferentiated state with endothelia growth factor and basic fibroblast growth factor as mitogens. IL 1 and striatal culture media further increased the number of TH immunoreactive cells. Transplantation of these neurons relieved the rotation symptom of PD rats.Conclusion:
Transplantation of mesencephalon progenitor cells has certain effects on PD rats.
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2001
Document type:
Article