Studies on sLe~(a/x) and Hematogenous Metastasis of Cancer / 中国生物工程杂志
China Biotechnology
; (12)2006.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-685484
Responsible library:
WPRO
ABSTRACT
The expression of sLea/x which correlates with conventional histopathologic parameters serves as a useful indicator for the prognosis of metastatic disease. The bindings between sLea/x and their common ligand E-selectin initiate hematogenous metastasis of cancer. Certain bioactive conformation is crucial for the interaction between sLea/x and their ligands. Thus, a new class of compounds that mimic the structures of sLea/x can potently inhibit not only their functional bindings to selectins, but also the metastasis of cancer. This review is mainly on the sLea/x molecular structure,biosynthesis,distribution, especially the relationship between sLea/x and hematogenous metastasis of cancer and the design of drugs that mimic the structures of sLea/x.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Biotechnology
Year:
2006
Document type:
Article