Impact of Age and Vascular Endothelial Function on Arterial Stiffness in Isolated Systolic Hypertersion / 中华高血压杂志

ABSTRACT

Objective To investigate the impact of aging and vascular endothelial function on arterial stiff- ness in patients with isolated systolic hypertension.Methods Patients with isolated systolic hypertension (ISH,n=75)age-matched healthy subjects(n=30)and young healthy subjects(n=50)were submitted to deter- mination of aortic pulse wave velocity(baPWV)and vascular endothelial function evaluated by flow-mediated dila- tion(FMD).Results baPWV was progresively decreased(ISH2459.2?436.8 vs elderly healthy2097.2? 315.7 vs young healthy1619.7?214.2 cm/s,P