Efficacy enhancement of a Baculovirus-vectored Newcastle Disease Virus F protein vaccine by chicken GM-CSF and IL-2 / 生物工程学报
Chinese Journal of Biotechnology
; (12): 1442-1452, 2018.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-687674
Responsible library:
WPRO
ABSTRACT
To compare with the effects of the GM-CSF and IL-2 used as adjuvants in the baculovirus vaccine, we used genetic engineering to construct the recombinant baculovirus rBV-LMI-F and with GM-CSF and IL-2 to immunized chickens. Then, we compared the concentration of the neutralizing antibody and cytokines to determine the immunostimulatory effects of GM-CSF and IL-2. GM-CSF induced higher levels of antibodies and cytokines in chickens at 28 d and 42 d post-vaccination. In conclusion, GM-CSF could elicit higher serum antibody and cytokines responses and improved the effects of Baculovirus vaccine.
Full text:
Available
Health context:
Sustainable Health Agenda for the Americas
Health problem:
Goal 10: Communicable diseases
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2018
Document type:
Article