Expression and Clinical Significances of HGFA, Matriptase, HAI-1 and HAI-2 in Acute Myeloid Leukemia / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 984-992, 2018.
Article
in Zh
| WPRIM
| ID: wpr-689541
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression and clinical significances of HGFA, Matriptase, HAI-1 and HAI-2 in patients with acute myeloid leukemia (AML).</p><p><b>METHODS</b>The bone marrow samples from 91 AML patients, 41 AML patients in complete remission, and 32 normal controls were collected. Real time fluorescence quantitative RT-PCR (qRT-PCR) was used to detect the mRNA expressions levels of HGFA, Matriptase, HAI-1, HAI-2 . The expressions of these genes were compared among AML untreated group, the complete remission group and the healthy control group. The correlation of their expression with clinical characteristics was analyzed.</p><p><b>RESULTS</b>The level of HGFA in the AML untreated group was higher than that in the healthy control group(P<0.05), while the HAI-2 mRNA level was lower than that in the healthy control group(P<0.05). The mRNA levels of HAI-1 and Matriptase were not changed significantly in all groups. The HAI-2 mRNA expression level was significantly lower in the high white blood cell group (P<0.05).</p><p><b>CONCLUSION</b>The abnormal activation of HGF/c-Met signaling system in AML may result from the increase of HGFA expression and the decrease of HAI-2 expression of the upstream regulatory factors.</p>
Full text:
1
Database:
WPRIM
Main subject:
Membrane Glycoproteins
/
Serine Endopeptidases
/
Leukemia, Myeloid, Acute
/
Hepatocyte Growth Factor
/
Proteinase Inhibitory Proteins, Secretory
Limits:
Humans
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2018
Document type:
Article