A preliminary study of the difference in composition of intestinal bifidobacteria between healthy infants and infants with allergic diseases / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 746-752, 2018.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-690096
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between intestinal bifidobacteria and allergic diseases in infants by comparing the composition of intestinal bifidobacteria between healthy infants and infants with allergic diseases.</p><p><b>METHODS</b>A total of 48 infants were enrolled, and fecal samples were collected on days 0, 2, 7, and 15 and at months 1, 6, and 12 after birth. Among these infants, 22 who experienced allergic diseases before the age of 1 year were enrolled as allergic group and 26 healthy infants were enrolled as healthy group. Quantitative real-time PCR was used for the qualitative and quantitative analyses of Bifidobacterium and 8 species of bifidobacteria in fecal samples.</p><p><b>RESULTS</b>There was a difference in the composition of intestinal bifidobacteria between the two groups within 1 month after birth the healthy group showed a reduction in bifidobacteria on day 2, while this feature was not observed in the allergic group. Compared with the healthy group, the allergic group had a significantly lower detection count of Bifidobacterium at month 1 (P<0.05) and a significantly lower detection rate of B.breve on day 15 (P<0.05), with delayed colonization of B.infantis.</p><p><b>CONCLUSIONS</b>Intestinal bifidobacteria and their composition within 1 month after birth may be associated with the development of allergic diseases, and this period of time may be a critical period for the prevention and treatment of allergic diseases in infants.</p>
Full text:
Available
Health context:
Sustainable Health Agenda for the Americas
Health problem:
Goal 1 Equitable access to health services
Database:
WPRIM (Western Pacific)
Type of study:
Qualitative research
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2018
Document type:
Article