Difference in Perioperative Management for Patients with and without Autism Spectrum Disorders undergoing General Anesthesia / 中国医学科学院学报

ABSTRACT

Objective To compare the difference in perioperative management for patients with or without autism spectrum disorders(ASD) undergoing general anesthesia. Methods We retrospectively analyzed the clinical data of 10 ASD patients(case group) and 10 non-ASD patients(control group) undergoing general anesthesia from January 2013 to February 2018. Both groups were matched by age,gender,and surgical procedures. The induction mode,premedication patterns,narcotic drugs,time to wake up,post-anesthesia care unit(PACU) stay,and perioperative vital signs were compared. Results The main induction mode was combined intravenous and inhaled anesthesia(CIIA) in case group(6/10) and total intravenous anesthesia(TIVA) in control group(10/10)(χ=8.571,P=0.003). The wake-up time are significantly longer in case group[(36.0±10.7) min] than in control group [(22.7±6.6)min] (t=18.000,P=0.005). Case group [(12.7±6.7)min] needed more time to obtain first vital sign than control group[(6.7±3.3)min](t=23.000,P=0.038). There were also significant differences in first systolic blood pressure (SBP)(t=15.500,P=0.007),preinductive SBP(t=24.000,P=0.048),and heart rate(t=22.000,P=0.033) between two groups. Conclusion Compared with non-ASD patients,ASD patients tend to use CIIA as the induction mode,have longer wake up time and later vital sign record,and are more likely to have peri-inductive vital signs.