Determination of flavonoids constituents in epimedium total flavone capsule and research on its anti-osteoporosis activity / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 3140-3144, 2018.
Article
in Zh
| WPRIM
| ID: wpr-690405
Responsible library:
WPRO
ABSTRACT
To develop a rapid resolution liquid chromatography (RRLC) method for the simultaneous determination of epimedoside A, epimedin A1, epimedin A, epimedin B, epimedin C, icariin, baohuosideⅡ, icarisideⅠ, sagittatoside B, 2"--rhamnosyl icarisideⅡ, and baohuosideⅠin epimedium total flavone capsule. At the same time, the effects of the above 11 compounds on osteogenic differentiation of MC3T3-E1 cells were investigated by detecting the content of alkaline phosphatase (AKP). The results showed that baohuoside Ⅱ had the highest activities, and both the activities of baohuoside Ⅱ and icariside Ⅰ were stronger than those of icariin.In this study, the content determination method of flavonoid glycosides was established, and the anti-osteoporosis effect of monomers was compared, providing technical support for the study of the pharmacodynamic and mechanism of Epimedium total flavone capsule.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2018
Document type:
Article