Effect of Coagulation and Platelet Activation on Tumor-Associated Hypercoagulable State in Lymphoma-Bearing Mice / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 427-431, 2018.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-690972
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the coagulation abnormality and tumor-associated hypercoagulable state in lymphoma-bearing mice by measuring the changes in coagulation indices (D-D, vWF, TF) and platelet activation indices (P-selectin, GPIIbIIIa).</p><p><b>METHODS</b>The mouse model with lymphoma was established by the subcutaneous injection of 38B9 lymphoma cells into BALB/c mice, and the tumor formation was evaluated by using MRI and B ultrasonography. The D-D, vWF and TP levels of blood samples from inner canthal vein of tumor-bearing mice on 1 d, 14 d and 21 d were detected by using ELISA, the platelet activation indices (P-selectin, GPIIbIIIa) were detected by using flow cytometry.</p><p><b>RESULTS</b>The lymphoma-bearing mouse model was successfully established. The levels of D-D, vWF and TF as well as platelet activation indices P-selectin and GPIIbIIIa in the peripheraI blood were significantly higher than those of control group (P<0.05).</p><p><b>CONCLUSION</b>Lymphoma-bearing mice showed abnormalities of coagulation and platelet activation, which relates with the tumor hypercoagulable state in lymphoma-bearing mice.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Blood Coagulation
/
Platelet Activation
/
P-Selectin
/
Thrombophilia
/
Lymphoma
/
Mice, Inbred BALB C
Limits:
Animals
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2018
Document type:
Article