The relationship between the expression of bone sialoprotein and the bone metastasis in women with breast cancer / 安徽医科大学学报

ABSTRACT

Objective To investigate the relationship between the expression of bone sialoprotein(BSP) and the bone metastasis of breast cancer.Methods 840 cases of female breast cancer patients were retrospectively analyzed.The patients were divided into breast cancer bone metastasis group and no bone metastasis group according to whether the patients had bone metastasis after treatment,BSP expression in paraffin specimens of 840 cases of primary breastcancer was determined by immunohistochemical method,x2 test and COX survival analysis was used in analysis of influencing factors of bone metastasis and 5 years survival after treatment of breast cancer.Results 840 cases of breast cancer postoperatively of single factor analysis showed that age,primary tumor size,clinical stage,TNM and molecular typing were statistically significant(P ＜0.05).BSP in bonemetastasis group was significantly higher than that in patients without bone metastasis(non metastasis group and bone metastasis group)(P ＜ 0.05).However,CerbB-2,lymph node metastasis,whether menopause,pathological type,cell grading showed no correla tion.Multivariate analysis revealed that age,tumor volume,clinicalstage,three negative breast and high expression of BPS were risk factors for bone metastasis.COX survival analysis of breast cancer 5 year survival rate,BSP high expression group and low expression group was statistically significant (P ＜ 0.05).Conclusion The clinical stage,age,primary lesion size and molecular type are the main risk factors for bone metastasis after breast cancer treatment.Bone sialoprotein expression is closely related to breast cancer bone metastasis.