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Serum nuclear magnetic resonance-based metabolomics in patients with diffuse large B-cell lymphoma: a pilot study / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma ; (12): 645-650, 2018.
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-691686
Responsible library: WPRO
ABSTRACT
Objective To discover new biomarkers for diffuse large B-cell lymphoma (DLBCL) diagnosis and prognosis using nuclear magnetic resonance (NMR)-based serum metabolomics. Methods High-resolution serum 1H NMR spectra were collected from 7 DLBCL patients and 7 healthy controls. Spectra were processed using stoichiometry pattern-recognition methods [principal component analysis (PCA) and orthogonal partial least squares discrimination analysis (OPLS-DA)]. Results Significant difference (P <0.05) in 9 metabolites was observed between DLBCL and healthy control by OPLS-DA (variable interpretation rate R2Y = 99.0 % and prediction rate Q2= 94.5 %). Compared with the healthy control group, higher levels of lactate (r =0.60, P<0.01), glycine (r =0.84, P<0.001), creatine (r =0.63, P<0.01), and choline (r =0.69, P< 0.01), lower levels of acetate (r= -0.88, P< 0.001), high-density lipoprotein (r= -0.77, P< 0.001), citrate (r =-0.82, P<0.001), glutamine (r =-0.53, P<0.05) and phosphocholine/glycerophosphocholine (r =-0.62, P<0.001) were detected in the serum samples of DLBCL. Conclusion The results of this study offer an evidence for significant changes between DLBCL patients and healthy people in serum metabolite profiles utilizing NMR-based serum metabolomics.

Full text: Available Database: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Journal of Leukemia & Lymphoma Year: 2018 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Journal of Leukemia & Lymphoma Year: 2018 Document type: Article
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