Risk factors for ovarian metastasis in endometrial carcinoma:a Meta analysis / 重庆医学

ABSTRACT

Objective To systematically evaluate the risk factors for ovarian metastasis of endometrial carcinoma(EC) to provide an evidence-based medicine basis for formulating the EC surgical mode and ovarian metastatic risk.Methods Studies about the risk factors for EC ovarian metastasis were retrieved by computer from the Pubmed,Embase,Cochrane Library,WanFang database,CNKI,China Biology Medicine(CBM) from Jan.1,1990 to Sep.1,2016.The quality evaluation of included literature was performed by using the Newcastle-Ottawa Scale(NOS).Results A total of 13 studies were included,involving 6 140 EC patients,of whom 344 cases(5.60％) had ovarian metastasis.The Meta analysis results showed that a total of 9 factors had statistical significance,which were deep myometrial infiltration(OR =0.28,95 ％ CI0.21-0.39),cervical involvement (OR =0.27,95 ％ CI0.16-0.45),lymph node involvement (OR =0.21,95 ％ CI0.15-0.27),fallopian tube involvement (OR =0.05,95 ％ CI0.02-0.10),non-endometrioid adenocarcinoma(OR=0.32,95％CI0.24-0.43),low differentiation(OR=0.39,95％CI0.31-0.50),positive ascites cytologic detection(OR=0.14,95％CI0.09-0.20),high serum CA125 level(OR=0.12,95％CI0.08-0.19) and lymphovascular cancer embolus(OR =0.34,95 ％ CI0.23-0.50),the differences were statistically significant(P＜0.05).But the age,lesion location,lesion diameter and estrogenic receptor level had no statistical difference(P＞0.05).Conclusion Deep myometrial infiltration,cervical involvement,lymph node involvement,fallopian tube involvement,non-endometrioid adenocarcinoma,low differentiation and positive ascites cytologic detection,high CA125 level and lymphovascular cancer embolus are the risk factors for EC ovarian metastasis.