Research progress of non-coding RNAs in sepsis-induced acute lung injury / 国际儿科学杂志

ABSTRACT

Non-ceding RNAs refer to a class of RNA molecules that do not have the function of coding proteins,mainly include microRNAs,long non-coding RNAs and cireular RNAs.Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection,which attacks the lung first.Recent studies have found that these non-coding RNAs,especially microRNAs,can regulate gene expression at various levels such as gene transcription,RNA maturation and protein translation,leading to the release and activation of proinflammatory and inflammatory mediators,the injury of vascular endothelial,and finally cause the lung injury.Researchers believe that non-coding RNAs appear to be not only diagnostic markers but also therapeutic targets for sepsis-induced acute lung injury.In this paper,the role and application of non-coding RNAs in sepsis-induced acute lung injury will be reviewed from their production and mechanism.