Maternal status of vitamin D and risk of childhood wheeze: a systematic review and meta-analysis / 国际儿科学杂志

ABSTRACT

Objective To assess the association between vitamin D levels during pregnancy and the risk of offspring's wheeze.Methods We searched electronic databases of PubMed and EMbasefrom published studies until July 2017.A random-effects meta-analysis was conducted among 11 birth cohort studies.Results Eleven studies on the association between maternal vitamin D status and childhood wheeze met our inclusion criteria.Maternal vitamin D status during pregnancy was associated with childhood wheeze(OR =0.97,95％ CI0.96 ～ 0.99).Maternal intake of vitamin D(pooled OR =0.51,95 ％ CI0.37 ～ 0.64),cord blood 25 (OH)D levels at birth (pooled OR =0.94,95％ CI0.9 ～ 0.98) were associated with childhood wheeze.Furthermore,maternal vitamin D stasus were only associated with childhood early wheeze(OR =0.92,95％ CI0.89 ～0.96),but not with late-onset or persistent wheeze.Conclusion High levels of vitamin D during pregnancy are inversely associated with the risk of wheeze during childhood.