The changes of serum iron markers in pregnant women with hepatitis B virus infection / 国际检验医学杂志

ABSTRACT

Objective To investigate the effect of hepatitis B virus(HBV)infection on serum iron markers in pregnant women.Methods A total of 188 pregnant women with HBV infection and 157 normal pregnant women were recruited in this study.Serum levels of iron,ferritin,transferrin,HBV DNA,alanine aminotrans-ferase(ALT)and aspartate aminotransferase(AST)were measured and compared.Results At the same stage of pregnancy,the serum ferritin level in pregnant women with HBV infection was higher than that of normal pregnant women(Z= -1.72,P=0.04;Z= -2.33,P=0.01;Z= -4.42,P=0.01),while the serum transfer-rin concentration increased in normal pregnant women in the second and third trimesters,and the differences between the two groups were statistically significant(Z= -3.26,P<0.01;Z= -2.25,P=0.01).In pregnant women with HBV infection,the serum ferritin levels in patients with positive results of ALT and AST were higher than those in patients with negative results(ALTP=0.01;ASTP=0.02),however,there was no change in healthy pregnant women.Conclusion There is iron metabolism imbalance in pregnant women with HBV infection.We should monitor serum iron markers to guide pregnant women for appropriate iron supple-mentation in gestation period.