The relationship between the expression of LncRNAs and the prognosis of bladder cancer patients:a Meta-analysis / 国际检验医学杂志

ABSTRACT

Objective To systematically uncover the correlation between the expression level of long chain non coding RNA(LncRNA)and the prognosis of bladder cancer patients Methods Databases including PubMed,Web of Science,and China National Knowledge Infrastructure(CNKI)were searched for relevant literatures about the the correlation between the expression level of LncRNAs and the prognosis of bladder cancer.After data were extracted,a Meta-analysis was performed using STATA12.0 software.Results A to-tal of 7 eligible studies including 722 cases were acquired from the databases that met the inclusion criteria. The Meta analysis showed that high expression of LncRNAs is associated with a shorter life period in patients with bladder cancer(HR=2.23,95% CI1.64 -3.04,P<0.01).Conclusion The high expression of LncR-NAs has a certain relationship with the poor prognosis of bladder cancer and is expected to be a potential bio-logical target for predicting the prognosis of bladder cancer.