Rine BLCA-4 test in the diagnosis of bladder cancer / 国际检验医学杂志

ABSTRACT

Objective To explore the urine BLCA-4 test application in the early diagnosis of bladder canc-er.Methods The patient is made up of three groups,62 cases of bladder cancer group,71 cases of bladder be-nign lesions group and 80 cases of healthy physical examination,morning urine specimen collection,ELISA was used to detection BLCA-4 content in morning urine,Statistical analysis differences of urine BLCA-4 ex-pression between three groups,and analysis the relationship between urine BLCA-4 content and the patients with bladder cancer clinical pathological indicators.Results Urine bladder cancer group BLCA-4 levels was higher than the bladder benign lesion group and healthy physical examination group(P<0.05),but no statisti-cal differences between bladder benign lesion group and healthy physical examination group(P>0.05).There is no statistical differences between stage Ta,stage T1-T2 and stage T3-T4,also no statistical differences be-tween G1 and G2-G3;The patients who tumor diameter≥3.0 cm patients urine BLCA-4 levels was higher than tumor diameter < 3.0 cm group(P< 0.05),The sensitivity、specificity and accuracy of diagnosis of urine BLCA-4 test in diagnosis of bladder cancer respectively,95.16%(59/62),97.35%(147/151)and 96.71%(206/213).Conclusion Urine BLCA-4 test has good sensitivity and specificity in diagnosis of bladder cancer, it is very important in bladder cancer screening and monitoring of recurrence of bladder cancer.