Reversal of P-glycoprotein-mediated multidrug resistance mechanism by curcumin / 国际肿瘤学杂志
Journal of International Oncology
; (12): 758-761, 2017.
Article
in Zh
| WPRIM
| ID: wpr-693403
Responsible library:
WPRO
ABSTRACT
Muhidrug resistance (MDR) is one of the important reasons for the failure of clinical anticancer drugs,involving multiple mechanisms.Among them,the classical MDR mechanism mediated by P-glycoprotein (P-gp) is closely related to the formation of MDR,which can excrete intracellular chemotherapeutic drugs through the "drug pump" effect and significantly reduce the therapeutic effect.Curcumin is mainly extracted from the underground rhizome of Chinese medicine turmeric,with a wide range of pharmacological activity.Recent studies have found that curcumin also has a role in reversing the MDR of the tumor,by inhibiting both P-gp function and expression,and this process involves a variety of signal paths.
Full text:
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Database:
WPRIM
Language:
Zh
Journal:
Journal of International Oncology
Year:
2017
Document type:
Article