Advances in CRISPR/Cas9 gene-editing system / 基础医学与临床
Basic & Clinical Medicine
; (12): 543-547, 2018.
Article
in Zh
| WPRIM
| ID: wpr-693937
Responsible library:
WPRO
ABSTRACT
CRISPR/Cas9 gene-editing system has been broadly used in various fields of bioscience and medicine in recent years. The system can be guided by RNA to specific DNA site thus achieving targeted gene editing.Off-target effect and editing efficiency remain to be two crucial challeges to the system. Currently, a number of researches have been focused on the optimization of the system by reducing off-target effects and increasing editing efficiency, which may enhance its safety and expand its application.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Basic & Clinical Medicine
Year:
2018
Document type:
Article