Research advances in serum markers for alcoholic liver fibrosis ZHANG Yanfang,HUANG Jing / 临床肝胆病杂志

ABSTRACT

Alcoholic liver fibrosis is a series of pathological changes caused by excessive intrahepatic deposition of fibrous connective tissue due to hepatocyte inflammation and necrosis caused by excessive drinking. Laboratory markers help with the differentiation of alcoholic liver disease,and a combination of these markers and examination of liver fibrosis can be used for the diagnosis of alcoholic liver fibrosis. Liver biopsy remains the gold standard for the diagnosis of liver fibrosis,but its clinical application is limited by its invasiveness. Therefore,more and more new serum molecular markers with a diagnostic value have been identified in recent years,and great breakthroughs have been made. In addition,a noninvasive diagnostic and predictive model based on various biochemical parameters and imaging findings also brings new hope to the diagnosis and treatment of liver fibrosis. This article reviews the recent research advances in the noninvasive diagnosis of al-coholic liver fibrosis by serum markers.