Research advances in polymorphisms of pancreatitis-associated genes / 临床肝胆病杂志

ABSTRACT

Mutations and polymorphisms of genes associated with pancreatic function are involved in the development and progression of pan-creatitis. In addition,systemic inflammatory response also affects the severity of pancreatitis,while mutations and polymorphisms of genes which encode inflammatory factors and cytokines can regulate the expression of such factors and thus affect the progression of systemic inflam-matory response. This article reviews the association between pancreatitis and polymorphisms of genes related to cationic trypsinogen,pancre-atic secretory trypsin inhibitor,cystic fibrosis conductance regulator,inflammatory factors,and cytokines.