The research progress on Notch signaling pathway in the regulation of Treg/Th17 cells / 天津医药

ABSTRACT

Notch family,a kind of important transmembrane signaling proteins,is highly evolutionarily conserved in the development process of multicellular organisms. Notch signaling pathway can precisely regulate cell development process through the interaction between neighboring cells,such as cell proliferation,differentiation and apoptosis.The regulatory T (Treg)cells and T helper 17(Th17)cells are new types of CD4+T cell subsets.In the physiological state of the organism,they can secrete relevant various kinds of cytokines,and systematically regulate the balance of immune system.In recent years, more and more studies have found that close relationship between Notch signaling pathway and Treg/Th17 cell balance, which is extensively involved in the various diseases. Therefore, this paper briefly reviewed the regulation mechanism of Notch signaling pathway on Treg/Th17 cells in diseases such as hematological diseases and autoimmune diseases.