Research advances in alarmins of ocular surface / 眼科新进展

ABSTRACT

Alarmins are endogenous mediators which transformed the early warning signals for immune system.Many studies have indicated that the expression of several alarmins was abnormal in the infectious and inflammatory diseases of ocular surface,such as high-mobility group box B protein 1,several antimicrobial peptides,interleukin33 and S100 proteins,which played multiple roles in those diseases,such as the effect of pro-inflammatory,anti-inflammatory,antimicrobial activity,wound healing.These studies are important for the pathogenesis and new therapeutic targets of ocular surface diseases.This review focus on the recent advances in alarmins of ocular surface.