Clinical effect of dexamethasone in the treatment of severe pregnancy induced hypertension with thrombocy- topenia syndrome / 中国基层医药

ABSTRACT

Objective To evaluate the clinical efficacy of dexamethasone in the treatment of severe pregnancy induced hypertension with thrombocytopenia syndrome .Methods 50 cases of severe pregnancy induced hypertension with thrombocytopenia syndrome were selected .The patients were randomly divided into the magnesium sulfate group and dexamethasone group according to the digital table ,25 cases in each group.The magnesium sulfate group was given magnesium sulfate treatment,the dexamethasone group was treated with dexamethasone .The treatment effect,the neonatal mortality rate,premature delivery rate,neonatal asphyxia rate,cesarean section rate,incidence of symptoms and prognosis were compared between the two groups .Results The effective rate of the dexamethasone group (92%) was higher than that of the magnesium sulfate group (68%,χ2 =5.164,P <0.05).The incidence rate of concurrent symptoms in the dexamethasone group (4%) was significantly lower than that in the magnesium sulfate group (20%,χ2 =4.287,P <0.05).The liver function recovery time,ALT recovery time,platelet recovery time in the dexametha-sone group were (3.12 ±1.23)d,(2.09 ±0.26)d,(2.45 ±0.25)d,respectively,which were obviously shorter than those in the magnesium sulfate group (t =3.011,3.872,3.456,all P <0.05).Conclusion Dexamethasone in the treatment of severe pregnancy induced hypertension with thrombocytopenia syndrome has prominent treatment effect , the neonatal mortality,premature birth,neonatal asphyxia rate,cesarean section rate and incidence rate of complica-tions are low,the prognosis is good,it is worthy of further study.