Effect of atorvastatin combined with coenzyme Q10 on early cardiac function in patients with coronary heart disease / 中国基层医药

ABSTRACT

Objective To investigate the clinical effect of atorvastatin combined with coenzyme Q 10 in the treatment of early cardiac dysfunction in patients with coronary heart disease .Methods From January 2015 to January 2017 ,86 patients with early cardiac dysfunction in the People's Hospital of Taierzhuang District were selected . According to the random number method ,the patients were divided into two groups ,with 43 patients in each group. The control group was treated with atorvastatin .The observation group was given atorvastatin combined with coenzyme Q10.All the patients were treated for 30 days.The levels of NT -porBNP and MMP -9 and the changes of echocardiographic parameters were compared between the two groups .Results After treatment, the levels of NT-porBNP and MMP -9 in the observation group were (150.1 ±20.1) pg/mL and (2.12 ±0.05)μg/L, respectively,which were lower than those in the control group (t=37.590,103.638,all P<0.05).The LVEDD and LVESD of the observation group were (46.0 ±3.6)mm and (41.5 ±2.9)mm,respectively,which were lower than those in the control group (all P<0.05).The LVEF of the observation group was (66.5 ±2.9)％,which was higher than that of the control group (P<0.05).Conclusion Atorvastatin combined with coenzyme Q10 treatment can significantly improve cardiac function and reduce myocardial injury .