A study on the effect of garlic to the heavy metal poisoning of rat
Journal of Korean Medical Science
; : 213-224, 1987.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-70230
Responsible library:
WPRO
ABSTRACT
When garlic (Allium sativum) was administered to rat per os simultaneously with cadmium, methylmercury and phenylmercury to detect the protective effect against the heavy metal poisoning, accumulation of heavy metals in liver, kidneys, bone and testes were decreased, and histopathological damages and the inhibition of serum alkaline phosphatase activities by heavy metals were reduced. Such effect of garlic was not shown in the 1.7% garlic treated group and most remarkable in the 6.7% garlic treated group. The protective effect of garlic was superior to those of 2,3 dimercapto-1-propanol (BAL) and D-penicillamine (PEN), and nearly similar to those of 2,3-dimercaptosuccinic acid (DMSA) and N-acetyl-DL-penicillamine (APEN), the current remedies, while garlic was not effective as a curative agent for heavy metal poisoning. The excretion of cadmium was enhanced, more through feces than urine by garlic but the effect to the urinary excretion of cadmium was not significant comparing with DMSA or APEN when cadmium was ip injected in the first 3 days during the 12 days of oral administration of DMSA, APEN or garlic.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Plants, Medicinal
/
Rats, Inbred Strains
/
Cadmium
/
Cadmium Poisoning
/
Tissue Distribution
/
Garlic
/
Mercury
/
Mercury Poisoning
Limits:
Animals
Language:
English
Journal:
Journal of Korean Medical Science
Year:
1987
Document type:
Article