CD226 involved in regulation of CD4+T cell / 中国免疫学杂志

ABSTRACT

CD226 is a typeⅠtransmembrane glycoprotein expressed on various immune cell membranes,such as NK cells,T cells,monocytes and other cells.After binding to ligand CD112 or CD155, CD226 mediates the differentiation, proliferation and functional regulation of various immune cells to participate many physiological and pathological activities.This paper mainly focuses on two aspects,the first is CD226 on CD4+T cell immune regulation, the seconds is the CD226 involved in the progress of many dis-ease.Detailed explanation of CD226 involved in naive CD4+T cell proliferation and differentiation, Th1/Th2/Th17 cells polarization and regulatory function of Treg cells.