Study on relationship between vascular endothelial growth factor and tumor burden / 中国免疫学杂志

ABSTRACT

Objective:To investigate the relationship between vascular endothelial growth factor ( VEGF ) and tumor burden. Methods: 100 cases of healthy volunteers,high risk of malignancy (family history of malignant tumors),without site lesions in patients with malignant tumor after operation,patients with stable disease after treatment,newly diagnosed malignancies were enrolled respectively,and recorded as control group,high-risk group,operation group,stable group and newly diagnosed group. The serum VEGF levels in the groups were quantitatively detected respectively,and the peripheral blood CD4+and CD8+were measured,then the CD4+/CD8+was calculated. The increasing rates and grading of VEGF, the serum VEGF levels and the CD4+/CD8+values were compared. Results: There was a significant difference in serum VEGF classification among the groups (P＜0. 05). The increasing rates of serum VEGF and the serum VEGF levels in the high-risk group,the operation group,the stable group and the newly diagnosed group were much higher than those in the control group (P＜0. 05),of which the CD4+and CD4+/CD8+values were much lower than those in the control group ( P＜0. 05) . The increasing rates of serum VEGF and the levels of serum VEGF in the operation group,the stable group and the newly diagnosed group were much higher than those in the high-risk group (P＜0. 05),of which the CD4+and CD4+/CD8+values were much lower than those in the high-risk group (P＜0. 05). The increasing rates of serum VEGF and the levels of serum VEGF in the stable group and the newly diagnosed group were much higher than those in the operation group (P＜0. 05),of which the CD4+and CD4+/CD8+values were much lower than those in the operation group (P＜0. 05). The increasing rates of serum VEGF and the level of serum VEGF in the newly diagnosed group were much higher than those in the stable group (P＜0. 05),of which the CD4+and CD4+/CD8+value were much lower than those in the stable group (P＜0. 05). The CD4+levels in the stable group and the newly diagnosed group were much lower than those in the control group,high-risk group,operation group (P＜0. 05). In the newly diagnosed group,serum VEGF level was negatively correlated with CD4+/CD8+(r=-0. 578,P＜0. 05). Conclusion: The level of serum VEGF in patients with malignant tumor increase in varying degrees,which also has certain relationships with cellular immune function,and it has reference value to determine the effect of the control of the tumor.