Is Antipsychotic Intake a Risk Factor for the Restless Legs Syndrome?
Journal of the Korean Neurological Association
; : 49-53, 2009.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-70320
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Restless-legs syndrome (RLS) is known to be caused by dopaminergic hypofunction in the brain. We investigated whether antipsychotics that act as antidopaminergics increase the risk of RLS.METHODS:
We prospectively recruited 72 schizophrenic patients who had been medicated with antipsychotic drugs in a psychiatry clinic. We evaluated RLS diagnostic criteria and basic sleep habits using the Epworth Sleepiness Scale and Pittsburgh Sleep Quality Index by face-to-face interviews using a structured questionnaire. We also applied the Unified Parkinson's Disease Rating Scale to evaluate extrapyramidal symptoms.RESULTS:
Three of the 72 patients (4.2%) met RLS criteria, which is similar to the previously reported RLS incidence among the general population in Korea.CONCLUSIONS:
There is no evidence that antipsychotics increase the risk of RLS. We believe that the mild antidopaminergic effect of antipsychotics does not overwhelm their prominent antipsychotic effect.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Parkinson Disease
/
Restless Legs Syndrome
/
Schizophrenia
/
Antipsychotic Agents
/
Brain
/
Incidence
/
Prospective Studies
/
Surveys and Questionnaires
/
Risk Factors
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Qualitative research
/
Risk factors
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Neurological Association
Year:
2009
Document type:
Article