Application value of superoxide dismutase with hepatitis B and hepatocellular carcinoma / 中国现代普通外科进展

ABSTRACT

Objective:To evaluate the activity of superoxide dismutase (SOD) in patients with hepatitis B and Hepatocellular carcinoma.Methods:63 cases of patients with hepatitis B,101 cases of patients with Hepatocellular carcinoma (HCC) and 58 cases of normal control were collected,serum enzyme activity of SOD was detected by enzyme method.Variance analysis were applied to analyze the difference of SOD activity in different groups.Receiver operating characteristic (ROC) were applied to analyze the diagnosis performance of SOD in hepatitis B and HCC patients.Results:SOD activity from high to low in turn was hepatitis B group191.500 U/mL,healthy contol group(179.766 ± 13.546 U/mL) and HCC group 150.000 U/mL,there were significant difference when compareing any two grougs (P＜0.05).SOD=187.20 U/mL could be used as diagnosis threshold in hepatitis B patients,the sensitivity was 65.08％ and the specificity was 75.86％.SOD=166.00 U/mL can be used as diagnosis threshold in HCC patients,the sensitivity was 82.18％ and the specificity was 84.48％.SOD=170.40 U/mL could be used as diagnosis threshold in HCC patients with AFP＜20 ng/mL,the sensitivity was 82.76％ and the specificity was 79.31％.Conclusions SOD activity varies in healthy person,hepatitis B and HCC patients.The changes of SOD activity could help us to understand whether there was transformation from hepatitis B to HCC.