Association of genetic variants of hTERT with susceptibility to hepatocellular carcinoma / 中国现代普通外科进展
Chinese Journal of Current Advances in General Surgery
; (4): 253-256, 2018.
Article
in Zh
| WPRIM
| ID: wpr-703800
Responsible library:
WPRO
ABSTRACT
Objective:To explore the correlation between several single-nucleotide polymorphisms (SNPs) loci on the gene of human telomerase reverse transcriptase (hTERT)(including rs2736100、rs2853676) and the susceptibility to Hepatocellular carcinoma in Qingdao area.Methods:This case-control study included 165 diagnosed Hepatocellular carcinoma,195 with chronic hepatitis B and 402 Healthy people.Polymerase chain restriction fragment length polymorphism were performed to analyze the genotype of the loci on the gene of hTERT.Results:The frequency of TT genotype on rs2736100 were higher in the Hepatocellular carcinoma group compared to the control group、chronic hepatitis B and no HCC people(P<0.05).The additive odds ratio of TT genotype for the risk of Hepatocellular carcinoma was 2.13、2.17 and 2.14.The frequency of AA genotype on rs2853676 were higher in the Hepatocellular carcinoma group compared to the control group、chronic hepatitis B and no HCC people (P<0.05).The additive odds ratio ofTT genotype for the risk of Hepatocellular carcinoma was 3.42、2.39 and 3.02.Conclusion:There was a relationship between hTERT rs2736100 and rs2853676 polymorphism and susceptibility to Hepatocellular carcinoma.
Full text:
1
Database:
WPRIM
Type of study:
Observational_studies
/
Risk_factors_studies
Language:
Zh
Journal:
Chinese Journal of Current Advances in General Surgery
Year:
2018
Document type:
Article