Analysis of 35 Cases of ADR Induced by Low-molecular Dextran and Amino Acid Injection in Our Hospital / 中国药房

ABSTRACT

OBJECTIVE:To investigate the characteristics and the regularity of ADR induced by Low-molecular dextran and amino acid injection,and to provide reference for safe use of drugs in clinic.METHODS:Among 35 cases of ADR induced by Low-molecular dextran and amino acid injection were collected from our hospital during Jan.2010-Jan.2017.Those ADR cases were analyzed statistically in respects of patients'gender and age,type and occurrence time of ADR cases,primary disease,aller gic history,organs/systems involved in ADR,clinical manifestations,outcomes,etc.RESULTS:Among 35 cases of ADR induced by Low-molecular dextran and amino acid injection,there were 18 male (51.43％) and 17 female (48.57％).The youngest patient was 11 years old,the oldest patient was 80 years old,the average age was 48.2 years.There were 4 cases of severe ADR (11.43 ％) and 31 cases of common ADR (88.57 ％).ADR mostly occurred 10 min-1 h after medication (71.43 ％).Bone fractures (14 cases,40.00％) and knee inflammation (8 cases,22.86％) were main original disease involved in ADR.Main organs or systems involved in ADR were digestive system(34.29％),circulatory system(22.86％),skin and its appendants (20.00％),etc.All cases were recovered or cured after drug withdrawal and systematic treatment.CONCLUSIONS:Low-molecular dextran and amino acid injection induce low incidence of ADR but can induce severe ADR.The nursing staff should strengthen ADR monitoring to reduce the occurrence of complications and avoid medical statf-patient dispute.