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Study on Tumor Drugs for Targeted Therapy Based on Micro-nanomotor / 中国药师
China Pharmacist ; (12): 779-783, 2018.
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-705591
Responsible library: WPRO
ABSTRACT

Objective:

To investigate the targeted motion and controllable release of tumor drugs based on micromotor.

Methods:

The directional movement of Janus micro-capsules was achieved through an external magnetic field,and the controllable release of tumor drugs was induced by near-infrared laser.

Results:

During the same period, the movement speed of the Janus capsules micromotor was the fastest(36.8 μm·s-1,approximately equalled to 3 body length·s-1) in 15% H2O2solution. Under the control of the external magnetic field, the Janus capsules micromotor could move along the scheduled trajectory close to the area of HeLa cells. Through the irradiation of near-infrared laser, the Janus capsules micromotor was broken and released the loaded drugs quickly.

Conclusion:

The Janus capsule micromotor studied in the paper can be used for targeted drug delivery safely and effectively,therefore,it shows good application prospect in the field of tumor diagnosis and treatment.

Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacist Year: 2018 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacist Year: 2018 Document type: Article
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