Comparison of clinicaopathological features of Henoch-Sch(o)nlein purpura nephritis with different proportions of crescent / 中国医师杂志

ABSTRACT

Objective Comparison of clinical and pathological features of Henoch-Sch(o)nlein purpura nephritis with different proportions of crescent.Methods Patients with Henoch Schonlein nephritis diagnosed by renal biopsy in our hospital from 2012 to 2017 (proportions of crescent ＜ 50％)were enrolled and grouped according to the rate of crescent formation (A groupcrescent formation rate ＜ 10％;B group10％-24％;C group＞ 24％-50％),their epidemiological,clinical manifestations,laboratory examination,clinicopathological features were compared.Results There was no significant difference between the three groups in sex,age and incidence of diabetes(P ＞ 0.05).The morbidity of hypertension in C group is higher than others (P ＜ 0.05).There were no different in the incidence of hematemesis,abdominal pain,joint pain in the three groups (P ＞0.05),while the incidence of edema and gross hematuria was significantly higher in group C than others.There were more patients had Nephritic syndrome (38.8％) in C group than the other groups (P ＜ 0.05).There was no significant difference in 24 h urinary protein,C-reactive protein (CRP),urine red blood cell,eosinophil granulocyte and immunoglobulin E (IgE) in the 3 groups.The levels of serum creatinine,blood urea nitrogen (BUN),and low density lipoprotein (LDL) increased significantly in group C,and the level of glomerular filtration rate (GFR) and albumin decreased significantly(P ＜ 0.05).The tubulointerstitial lesions,mesangial cell proliferation and deposition of C1q levels,C group was significantly higher than the other two groups (P ＜ 0.05).Conclusions In Henoch Sch(o)nlein purpura nephritis,with the increase of the proportion of the crescent body,the renal function and pathological changes of the kidney are gradually aggravated.Therefore,the crescent is important for the prognosis of Henoch Sch(o)nlein purpura nephritis.