Application of novel proteasome inhibitors in treating multiple myeloma / 中国肿瘤临床

ABSTRACT

Multiple myeloma (MM) is a hematologic malignancy of clonal proliferation of plasma cells, which ranks the second in he-matologic malignancy. Proteasome is a complex enzyme in the cell, which can degrade ubiquitin-labeled proteins and regulate intracel-lular protein levels and play an important role in maintaining the stability of the intracellular environment. In recent years, with the ap-plication of new proteasome inhibitors, great progress has been achieved in MM treatment, further improving the therapeutic efficacy of myeloma.