Research progress in topical hemostatic agents for war injury / 中华创伤杂志

ABSTRACT

Effective and rapid hemostasis is the key to reduce the mortality of war injuries and has been the focus of tactical war injury treatment (TCCC) in recent years. With the changes of battlefield and trauma, the higher demand for trauma hemostasis promotes the fast development of new hemostasis concept and methods. At present, there are a wide variety of topical hemostasis materials or products with different mechanisms of action, all of which are aimed at first aid, self rescue, and rapid treatment of wounds in wartime. Efficient topical hemostasis materials or products can quickly promote coagulation, prevent serious bleeding, and reduce the death of war injuries, thus being suitable for the field battle. Therefore, it is an inevitable trend to develop highly efficient hemostatic products catering to diverse needs. In this article, we briefly review the mechanism, efficiency, and some deficiencies of several novel hemostatic agents such as chitosan and zeolite, and provide new outlook for the research of current rapid hemostatic products. It provides a theoretical basis for development of hemostasis medical materials and instruments for severe combat trauma, especially penetrating injury or high-energy explosive injury.